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The complete scientific resource for Inositols, Phosphoinositides, Phosphatidylinositols, and other essential cell signaling molecules.

Phosphoinositides play a central role in the regulation of numerous cell signaling processes. Their involvment in cytoskeletal remodeling, vesicle trafficking, cell survival, mitogenesis, DNA repair, transcription regulation, exo-endocytosis, ion channel modulation, phagocytosis, apoptosis have been reported.

Inositols.com serves as a web resource for researching & sourcing tools specific to the inositol / phosphoinositide signaling field.

Selected Scientific Reviews

  1. 1. Hammond G, Thomas CL, Schiavo G. Nuclear phosphoinositides and their functions. Curr Top Microbiol Immunol. 2004; 282:177-206.
  2. 2. Botelho RJ, Scott CC, Grinstein S. Phosphoinositide involvement in phagocytosis and phagosome maturation. Curr Top Microbiol Immunol. 2004;282:1-30.
  3. 3. Lemmon MA. Phosphoinositide recognition domains. Traffic. 2003. Apr;4(4):201-13.
  4. 4. Yin HL, Janmey PA. Phosphoinositide regulation of the actin cytoskeleton. Annu Rev Physiol. 2003;65:761-89. Epub 2002 May 01.
  5. 5. Tronchere H, Buj-Bello A, Mandel JL, Payrastre B. Implication of phosphoinositide phosphatases in genetic diseases: the case of myotubularin. Cell Mol Life Sci. 2003. Oct;60(10):2084-99.
  6. 6. Nahorski SR, Young KW, John Challiss RA, Nash MS. Visualizing phosphoinositide signalling in single neurons gets a green light. Trends Neurosci. 2003 Aug;26(8):444-52.
  7. 7. Cantley LC. The phosphoinositide 3-kinase pathway. Science. 2002. May 31;296(5573):1655-7.
  8. 8. Kanaho Y, Suzuki T. Phosphoinositide kinases as enzymes that produce versatile signaling lipids, phosphoinositides. J Biochem (Tokyo). 2002 Apr;131(4):503-9.
  9. 9. Toker A. Phosphoinositides and signal transduction. Cell Mol Life Sci. 2002. May;59(5):761-79.
  10. 10. De Matteis M, Godi A, Corda D. Phosphoinositides and the golgi complex. Curr Opin Cell Biol. 2002 Aug;14(4):434-47.
  11. 11. Majerus PW. Inositols do it all. Genes Dev. 1996. May 1;10(9):1051-3.
  12. 12. Allen-Baume V, Segui B, Cockcroft S. Current thoughts on the phosphatidylinositol transfer protein family. FEBS Lett. 2002. Oct 30;531(1):74-80.
  13. 13. Cooke FT. Phosphatidylinositol 3,5-bisphosphate: metabolism and function. Arch Biochem Biophys. 2002. Nov 15;407(2):143-51.
  14. 14. Osborne SL, Meunier FA, Schiavo G. Phosphoinositides as key regulators of synaptic function. Neuron. 2001. Oct 11;32(1):9-12.
  15. 15. Tolias KF, Cantley LC. Pathways for phosphoinositide synthesis. Chem Phys Lipids. 1999. Apr;98(1-2):69-77.

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